| 货号 | 13338-1mg |
| 描述 | The Src family of proto-oncogenic kinases include nine mammalian non-receptor tyrosine kinases that are involved in intracellular signaling and are often relevant to carcinogenesis. SU6656 is a selective inhibitor of Src kinases, Including Src, Yes, Lyn, and Fyn (IC50 = 280, 20, 130, 170 nM, respectively).1 It weakly inhibits some other kinases when used at >10 μM.1,2 SU6656 has been used to study the role of Src kinases in cell growth and development in diverse processes, including nervous system development, fibrosis, and cancer.3,4,5 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Blake, R.A.,Broome, M.A.,Liu, X., et al. SU6656, a selective Src family kinase inhibitor, used to probe growth factor signaling. Molecular and Cellular Biology 20(23), 9018-9027 (2000). 2.Bain, J.,McLauchlan, H.,Elliot, M., et al. The specificities of protein kinase inhibitors: An update. Biochemistry Journal 371, 199-204 (2003). 3.Jin, W.,Yun, C.,Jeong, J., et al. c-Src is required for tropomyosin receptor kinase C (TrkC)-induced activation of the phosphatidylinositol 3-kinase (PI3K)-AKT pathway. The Journal of Biological Chemisty 283(3), 1391-1400 (2008). 4.Distler, J.H.W., and Distler, O. Intracellular tyrosine kinases as novel targets for anti-fibrotic therapy in systemic sclerosis. Rheumatology 47, 10-11 (2008). 5.Fossey, S.L.,Liao, A.T.,McCleese, J.K., et al. Characterization of STAT3 activation and expression in canine and human osteosarcoma. BMC Cancer 9, (2009). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 371.5 |
| 分子式 | C19H21N3O3S |
| CAS号 | 330161-87-0 |
| 稳定性 | ≥ 2 years |
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