H-9 (hydrochloride)
货号：
13312-5mg 基本售价：
294.0 元 规格：
5 mg
产品信息
概述| 货号 | 13312-5mg |
| 描述 | The H series isoquinolinesulfonamide protein kinase inhibitors are widely used to block signaling pathways in order to elucidate mechanisms of cellular regulation and signal transduction. H-9 (hydrochloride), an isoquinolinesulfonamide protein kinase inhibitor, is a competitive inhibitor of PKC, PKG, and PKA with Ki values of 18, 0.87, and 1.9 µM, respectively.1 H-9 (hydrochloride) has been used to reduce the cAMP-mediated excitatory response to serotonin in C. elegans enteric neurons2 and to inhibit PKA-mediated phosphorylation in a rat seizure model.3 |
| 别名 | Protein Kinase Inhibitor H-9; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Hidaka, H.,Inagaki, M.,Kawamoto, S., et al. Isoquinolinesulfonamides, novel and potent inhibitors of cyclic nucleotide dependent protein kinase and protein kinase C. Biochemistry 23, 5036-5041 (1984).
2.Papaioannou, S.,Holden-Dye, L., and Walker, R.J. Evidence for a role for cyclic AMP in modulating the action of 5-HT and an excitatory neuropeptide, FLP17A, in the pharyngeal muscle of Caenorhabditis elegans. Invertebrate Neuroscience 8, 91-100 (2008).
3.Vázquez-López, A.,Sierra-Paredes, G., and Sierra-Marcuño, G. Role of cAMP-dependent protein kinase on acute picrotoxin-induced seizures. Neurochemical Research 30(5), 613-618 (2005).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 324.2 |
| 分子式 | C11H13N3O2S • 2HCl |
| CAS号 | 116700-36-8 |
| 稳定性 | ≥ 2 years |
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