CP 80,633
货号：
13183-500ug 基本售价：
294.0 元 规格：
500 ug
产品信息
概述| 货号 | 13183-500ug |
| 描述 | Phosphodiesterases (PDE) enzymatically convert the cyclic nucleotide second messengers cAMP and cGMP to 5’-AMP and 5’-GMP, respectively, thus terminating signal transduction. The cAMP-specific PDE4 isoforms may be particularly important in certain respiratory and neurological diseases. CP 80,633 is a selective inhibitor of PDE4 (IC50 = 1.27 μM for PDE4 versus. >100 μM for PDE1, PDE2, PDE3, and PDE5).1 It potentiates PGE1-dependent increases in cAMP levels in eosinophils, monocytes, and T-cells, inhibits eosinophil superoxide production (IC50< 0.6 μM), and blocks LPS-induced TNF-α release from monocytes (IC50 = 0.22 μM).1 CP 80,633 (1 mg/kg) significantly reduces antigen-induced airway inflammation in atopic guinea pigs, monkeys, and mice.2,3 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Cohan, V.L.,Showell, H.J.,Fisher, D.A., et al. In vitro pharmacology of the novel phosphodiesterase type 4 inhibitor, CP-80633. Journal of Pharmacology and Experimental Therapeutics 278(3), 1356-1361 (1996).
2.Turner, C.R.,Cohan, V.L.,Cheng, J.B., et al. The in vivo pharmacology of CP-80, 633, a selective inhibitor of phosphodiesterase 4. Journal of Pharmacology and Experimental Therapeutics 278(3), 1349-1355 (1996).
3.Cheng, J.B.,Watson, J.W.,Pazoles, C.J., et al. The phosphodiesterase type 4 (PDE4) inhibitor CP-80,633 elevates plasma cyclic AMP levels and decreases tumor necrosis factor-α (TNFα) production in mice: Effect of adrenalectomy. Journal of Pharmacology and Experimental Therapeutics 280, 621-626 (1997).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 316.4 |
| 分子式 | C18H24N2O3 |
| CAS号 | 135637-46-6 |
| 稳定性 | ≥ 2 years |
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