| 货号 | 10574-100mg |
| 描述 | Suberohydroxamic acid (SBHA) is a competitive histone deacetylase (HDAC) inhibitor that has been shown to inhibit HDAC1 (IC50 = 0.25 μM) and HDAC3 (IC50 = 0.30 μM).1 SBHA causes cell differentiation, cell cycle arrest, or apoptosis.2,3,4,5,6 HDAC inhibitors, including SBHA, act synergistically to kill cancer cells when used in combination with cytostatic drugs, allowing lower doses of both inhibitors and drugs to be used.7,8 |
| 别名 | SBHA;Subericbis-Hydroxamic Acid; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Richon, V.M.,Emiliani, S.,Verdin, E., et al. A class of hybrid polar inducers of transformed cell differentiation inhibits histone deacetylases. Proceedings of the National Academy of Sciences of the United States of America 95, 3003-3007 (1998). 2.Brinkmann, H.,Dahler, A.L.,Popa, C., et al. Histone hyperacetylation induced by histone deacetylase inhibitors is not sufficient to cause growth inhibition in human dermal fibroblasts. The Journal of Biological Chemisty 276(25), 22491-22499 (2001). 3.You, B.R. and Park, W.H. Suberoyl bishydroxamic acid inhibits the growth of A549 lung cancer cells via caspase-dependent apoptosis. Molecular and Cellular Biochemistry (2010). 4.Ning, L.,Greenblatt, D.Y.,Kunnimalaiyaan, M., et al. Suberoyl bis-hydroxamic acid activates Notch-1 signaling and induces apoptosis in medullary thyroid carcinoma cells. Oncologist 13, 98-104 (2008). 5.Zhang, X.D.,Gillespie, S.K.,Borrow, J.M., et al. The histone deacetylase inhibitor suberic bishydroxamate regulates the expression of multiple apoptotic mediators and induces mitochondria-dependent apoptosis of melanoma cells. Molecular Cancer Therapeutics 3(4), 425-435 (2004). 6.Zhang, X.D.,Gillespie, S.K.,Borrow, J.M., et al. The histone deacetylase inhibitor suberic bishydroxamate: A potential sensitizer of melanoma to TNF-related apoptosis-inducing ligand (TRAIL) induced apoptosis. Biochemical Pharmacology 66, 1537-1545 (2003). 7.Flis, S.,Gnyszka, A.,Flis, K., et al. MS275 enhances cytotoxicity induced by 5-fluorouracil in the colorectal cancer cells. European Journal of Pharmacology 627, 26-32 (2010). 8.Flis, S.,Gnyszka, A. and Splawinski, J. HDAC inhibitors, MS275 and SBHA, enhances cytotoxicity induced by oxaliplatin in the colorectal cancer cell lines. Biochemical and Biophysical Research Communications 387, 336-341 (2009). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 204.2 |
| 分子式 | C8H16N2O4 |
| CAS号 | 38937-66-5 |
| 稳定性 | ≥ 2 years |
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