| 货号 | 10010740-1mg |
| 描述 | Cellular prion protein (PrPc) is a cell surface glycoprotein expressed in brain, spinal cord, and several peripheral tissues that if mutated to the protease-resistant isoform PrPSc (scrapie PrP, PrPres) can result in one of several fatal neurodegenerative diseases.1 Prion diseases, including mad cow disease (bovine spongiform encephalopathy), scrapie, and Creutzfeldt-Jakob disease develop from the accumulation of PrPSc, an abnormally folded β-rich conformation of PrPc.2,3 CAY10550 is a potent antiprion compound that inhibits the accumulation of PrPc with an IC50 value of 3 nM in both ScN2a and F3 prion-infected mouse neuroblastoma cell lines.4 This compound also demonstrates moderate radical scavenging activity as it inhibits the formation of hydroxyl radicals in vitro with an IC50 value of 90 µM.4 |
| 别名 | 3-(4-Nitrophenyl)-1-phenyl-2-pyrazolin-5-one; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Prusiner, S.B. Shattuck lecture-neurodegenerative diseases and prions. New England Journal of Medicine 344(20), 1516-1526 (2001). 2.Stahl, N. and Prusiner, S.B. Prions and prion proteins. The FASEB Journal 5, 2799-2807 (1991). 3.Prusiner, S.B. Prions. Proceedings of the National Academy of Sciences of the United States of America 95, 13363-13383 (1998). 4.Kimata, A.,Nakagawa, H.,Ohyama, R., et al. New series of antiprion compounds: Pyrazolone derivatives have the potent activity of inhibiting protease-resistant prion protein accumulation. Journal of Medicinal Chemistry 50, 5053-5056 (2007). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 281.3 |
| 分子式 | C15H11N3O3 |
| CAS号 | 34320-83-7 |
| 稳定性 | ≥ 2 years |
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