LY223982
货号：
10010024-1mg 基本售价：
294.0 元 规格：
1 mg
产品信息
概述| 货号 | 10010024-1mg |
| 描述 | Leukotriene B4(LTB4) is a dihydroxy fatty acid derived from the 5-lipoxygenase pathway of arachidonic acid metabolism and is an important mediator of the inflammatory process. The benzophenone dicarboxylic acid derivative LY223982 is a potent BLT1 receptor antagonist. It inhibits the specific binding of radiolabeled-LTB4 to isolated human neutrophils with an IC50 value of 13.2 nM.1 LY223982 inhibits the leukotriene B4(LTB4)-induced aggregation of guinea pig and human neutrophils with IC50 values of 74 and 100 nM, respectively.2 However, concentrations of LY223982 up to 10 µM do not inhibit binding of LTB4 to human BLT1 or BLT2 expressed in CHO cells.3 |
| 别名 | CGS 23131;SKF 107324; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Gapinski, D.M.,Mallett, B.E.,Froelich, L.L., et al. Benzophenone dicarboxylic acid antagonists of leukotriene B4. 2. Structure-activity relationships of the lipophilic side chain. Journal of Medicinal Chemistry 33, 2807-2813 (1990).
2.Jackson, W.T.,Boyd, R.J.,Froelich, L.L., et al. Specific inhibition of leukotriene B4-induced neutrophil activation by LY223982. Journal of Pharmacology and Experimental Therapeutics 263(3), 1009-1014 (1992).
3.Yokomizo, T.,Kato, K.,Hagiya, H., et al. Hydroxyeicosanoids bind to and activate the low affinity leukotriene B4 receptor, BLT2. The Journal of Biological Chemisty 276(15), 12454-12459 (2001).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 502.6 |
| 分子式 | C30H30O7 |
| CAS号 | 117423-74-2 |
| 稳定性 | ≥ 2 years |
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