Maslinic Acid
货号：
10009645-1mg 基本售价：
294.0 元 规格：
1 mg
产品信息
概述| 货号 | 10009645-1mg |
| 描述 | Maslinic acid is found in a number of natural sources, most notably pomace olive oil (orujo). This pentacyclic triterpene has an antiproliferative effect against Caco-2 cancer cells (EC50 = 15 µM), HT-29 human colon cancer cells (EC50 = 74 µM), 1321N1 astrocytoma cells (IC50 = 25 µM), and human leukemia (CCRF-CEM and CEM/ADR5000) cells (IC50 = 7 µM and 9 µM respectively).1,2,3,4 Maslinic acids antiproliferative activity likely comes from the induction of an oxidative apoptotic pathway, causing cell cycle and cytoskeleton alterations. Maslinic acid has been found to attenuate intracellular oxidative stress via inhibition of NO and H2O2 production and reduction of pro-inflammatory cytokine generation in murine macrophages.5 Recently maslinic acid has been found to inhibit the spread of the HIV virus by inhibiting the replication of a primary HIV-1 isolate as well as decreased the cytopathic effect and p24 antigen levels in MT2 cells.6 |
| 别名 | Crategolic Acid;2α-Hydroxyoleanoic Acid; |
性能| 供应商 | Cayman |
| 应用文献 |
1.He, X., and Liu, R.H. Triterpenoids isolated from apple peels have potent antiproliferative activity and may be partially responsible for apple’s anticancer activity. Journal of Agricultural and Food Chemistry 55, 4366-4370 (2007).
2.Martín, A.M.,De La Puerta Vázquez, R.,Fernández-Arche, A., et al. Supressive effect of maslinic acid from pomace olive oil on oxidative stress and cytokine production in stimulated murine macrophages. Free Radical Research 40(3), 295-302 (2006).
3.García, A. Compound from olive-pomace oil inhibits HIV spread. 070709111536, 1-1 (2007).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | >98% |
| 计算分子量 | 472.7 |
| 分子式 | C30H48O4 |
| CAS号 | 4373-41-5 |
| 稳定性 | ≥ 2 years |
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