CAY10508
货号：
10008669-5mg 基本售价：
294.0 元 规格：
5 mg
产品信息
概述| 货号 | 10008669-5mg |
| 描述 | Central cannabinoid (CB1) receptor antagonists and inverse agonists exhibit therapeutic potential for obesity and drug dependence, while being devoid of psychotropic effects. CAY10508 is a potent and selective central cannabinoid (CB1) receptor inverse agonist with a Ki value of 243 nM and an EC50 of 195 nM.1 A 10 µM concentration of CAY10508 resulted in 100% and 35% displacement of [3H]-CP-55,940 at the CB1 and peripheral cannabinoid (CB2) receptors, respectively. A [35S]-GTPγS binding assay revealed the inverse agonist properties of CAY10508 at the CB1receptor. |
性能| 供应商 | Cayman |
| 应用文献 |
1.Muccioli, G.G.,Wouters, J.,Charlier, C., et al. Synthesis and activity of 1,3,5-triphenylimidazolidine-2,4-diones and 1,3,5-triphenyl-2-thioxoimidazolidin-4-ones: Characterization of new CB1 cannabinoid receptor inverse agonists/antagonists. Journal of Medicinal Chemistry 49, 872-882 (2006).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 486.2 |
| 分子式 | C21H14Br2N2O2 |
| CAS号 | 878533-35-8 |
| 稳定性 | ≥ 2 years |
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