JNJ-10198409
货号：
10008131-1mg 基本售价：
294.0 元 规格：
1 mg
产品信息
概述| 货号 | 10008131-1mg |
| 描述 | Inhibition of the tyrosine kinase activity of growth factor receptors such as the platelet-derived growth factor (PDGF-BB) receptor can have potent antiangiogenic and antiproliferative activity.1 JNJ-10198409 is a small molecule inhibitor of platelet-derived growth factor (PDGF-BB) tyrosine kinase with an IC50 value of 4.2 nM when tested in human coronary artery smooth muscle cells.2 JNJ-10198409 is a competitive antagonist of the ATP binding and hydrolysis at this receptor, resulting in a dose dependent inhibition of tumor growth and angiogenesis. |
性能| 供应商 | Cayman |
| 应用文献 |
1.Battegay, E.J.,Rupp, J.,Iruela-Arispe, L., et al. PDGF-BB modulates endothelial proliferation and angiogenesis in vitro via PDGF β-receptors. Journal of Cell Biology 125(4), 917-928 (1994).
2.Ho, C.Y.,Ludovici, D.W.,Maharoof, U.S.M., et al. (6,7-Dimethoxy-2,4-dihydroindeno[1,2-c]pyrazol-3-yl)phenylamines: Platelet-derived growth factor receptor tyrosine kinase inhibitors with broad antiproliferative activity against tumor cells. Journal of Medicinal Chemistry 48, 8163-8173 (2005).
|
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 325.3 |
| 分子式 | C18H16FN3O2 |
| CAS号 | 627518-40-5 |
| 稳定性 | ≥ 2 years |
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