| 货号 | 10007705-1mg |
| 描述 | Molecules having vitamin E antioxidant activity include four tocopherols (α, β, δ, and γ) and four tocotrienols (α, β, δ, and γ).1 α-Tocopherol is the major lipid soluble antioxidant in vivo and protects against lipid peroxidation.2 α-CEHC is the major urinary metabolite of α-tocopherol following vitamin E supplementation.3 The concentration of α-CEHC in human serum is in the range of 5-10 pmol/ml but increases significantly up to 200 pmol/ml upon supplementation with RRR-α-tocopherol. About one-third of the α-CEHC circulating in the blood is present as a glucuronide conjugate.4 α-CEHC was only excreted when a threshold concentration of 7-9 µmol α-tocopherol/g total lipid in plasma was exceeded. Therefore, excretion of α-CEHC may be considered to be a marker of optimum vitamin E intake.5 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Kamal-Eldin, A., and Appelqvist, L.Å. The chemistry and antioxidant properties of tocopherols and tocotrienols. Lipids 31, 671-701 (1996). 2.Burton, G.W.,Joyce, A., and Ingold, K.U. Is vitamin E the only lipid-soluble, chain-breaking antioxidant in human blood plasma and erythrocyte membranes? Archives of Biochemistry and Biophysics 221(1), 281-290 (1983). 3.Traber, M.G.,Elsner, A., and Brigelius-Flohé, R. Synthetic as compared with natural vitamin E is preferentially excreted as α-CEHC in human urine: Studies using deuterated α-tocopheryl acetates. FEBS Letters 437, 145-148 (1998). 4.Stahl, W.S.,Graf, P.,Brigelius-Flohé, R., et al. Quantification of the α- and γ-tocopherol metabolites 2,5,7,8-tetramethyl-2-(2-carboxyethyl)-6-hydroxychroman and 2,7,8-trimethyl-2-(2-carboxyethyl)-6-hydroxychroman in human serum. Analytical Biochemistry 275, 254-259 (1999). 5.Schultz, M.,Leist, M.,Petrzika, M., et al. Novel urinary metabolite of α-tocopherol, 2,5,7,8-tetramethyl-2(2-carboxyethyl)-6-hydroxychroman, as an indicator of an adequate vitamin E supply. American Journal of Clinical Nutrition 62(6), 1527S-1534S (1995). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 278.3 |
| 分子式 | C16H22O4 |
| CAS号 | 4072-32-6 |
| 稳定性 | ≥ 2 years |
| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |