2,4-Diamino-6-hydroxypyrimidine
货号：
81260-1g 基本售价：
280.0 元 规格：
1 g
产品信息
概述| 货号 | 81260-1g |
| 描述 | 2,4-Diamino-6-hydroxypyrimidine (DAHP) is a selective, specific inhibitor of GTP cyclohydrolase I, the rate limiting step for de novo pterin synthesis. In HUVEC cells, the IC50 for inhibition of BH4 biosynthesis is about 0.3 mM. DAHP can be used to effectively block NO production in several cell types.1,2,3 |
| 别名 | DAHP; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Werner-Felmayer, G.,Werner, E.R.,Fuchs, D., et al. Pteridine biosynthesis in human endothelial cells. Impact on nitric oxide-mediated formation of cyclic GMP. The Journal of Biological Chemisty 268, 1842-1846 (1993).
2.Sung, Y.J.,Hotchkiss, J.H., and Dietert, R.R. 2,4-Diamino-6-hydroxypyrimidine, an inhibitor of GTP cyclohydrolase I, suppresses nitric oxide production by chicken macrophages. International Journal of Immunopharmacology 16, 101-108 (1994).
3.Gross, S.S., and Levi, R. Tetrahydrobiopterin synthesis. An absolute requirement for cytokine-induced nitric oxide generation by vascular smooth muscle. The Journal of Biological Chemisty 267, 25722-25729 (1992).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 126.1 |
| 分子式 | C4H6N4O |
| CAS号 | 56-06-4 |
| 稳定性 | ≥ 1 year |
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