Memantine (hydrochloride)
货号：
14184-10mg 基本售价：
280.0 元 规格：
10 mg
产品信息
概述| 货号 | 14184-10mg |
| 描述 | Memantine is an N-methyl-D-aspartate (NMDA) open-channel blocker (Ki = 1.2 μM at -60 mV) and uncompetitive antagonist with known anti-Parkinsonian, anti-epileptic, anti-stroke, and anti-Alzheimer’s disease properties.1,2,3 At 12 μM memantine blocks 90% of NMDA receptor activity and prevents NMDA-receptor mediated neurotoxicity resulting from excessive levels of glutamate in rat cortical and retinal ganglion cell neurons.1 |
| 别名 | Akatinol;Axura;Ebix;Namenda;NSC 102290;SUN Y7017; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Chen, H.S.V.,Pellegrini, J.W.,Aggarwal, S.K., et al. Open-channel block of N-methyl-D-aspartate (NMDA) responses by memantine: Therapeutic advantage against NMDA receptor-mediated neurotoxicity. Journal of Neuroscience 12(11), 4427-4436 (1992).
2.Fredholm, B.B.,Chern, Y.,Franco, R., et al. Aspects of the general biology of adenosine A2A signaling. Progress in Neurobiology 83, 263-276 (2007).
3.Helmuth, L. New Alzheimer’s treatments that may ease the mind. Science 297, 1260-1262 (2002).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | 22 |
| 纯度 | ≥98% |
| 计算分子量 | 215.8 |
| 分子式 | C12H21N • HCl |
| CAS号 | 41100-52-1 |
| 稳定性 | ≥ 2 years |
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