| 货号 | 13320-100g |
| 描述 | MCI-186 is a free radical scavenger with diverse protective effects in vivo. Most notably, it reduces damage due to ischemia-reperfusion injury in lung, liver, and brain in animal models of transplant, infection, traumatic brain injury, and stroke.1,2,3,4 MCI-186 provides these protective effects, at least in part, by reducing reactive oxygen species, inhibiting apoptosis, and blocking nonenzymatic peroxidation and lipoxygenase activity.3,5,6 |
| 别名 | Edaravone;NSC 2629; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Xu, J.z.,Shen, B.z.,Li, Y., et al. Edaravone attenuates ischemia-reperfusion injury by inhibiting oxidative stress in a canine lung transplantation model. Chinese Medical Journal 121(16), 1583-1587 (2008). 2.Kono, H.,Asakawa, M.,Fujii, H., et al. Edaravone, a novel free radical scavenger, prevents liver injury and mortality in rats administered endotoxin. Journal of Pharmacology and Experimental Therapeutics 307(1), 74-82 (2003). 3.Gao, Y.,Ding, X.s.,Xu, S., et al. Neuroprotective effects of edaravone on early brain injury in rats after subarachnoid hemorrhage. Chinese Medical Journal 122(16), 1935-1940 (2009). 4.Kikuchi, K.,Kawahara, K.i.,Tancharoen, S., et al. The free radical scavenger edaravone rescues rats from cerebral infarction by attenuating the release of high-mobility group box-1 in neuronal cells. Journal of Pharmacology and Experimental Therapeutics 329(3), 865-874 (2009). 5.Rajesh, K.G.,Sasaguri, S.,Suzuki, R., et al. Antioxidant MCI-186 inhibits mitochondrial permeability transition pore and upregulates Bcl-2 expression. American Journal of Physiology.Heart and Circulatory Physiology 285, H2171-H2178 (2003). 6.Abe, K.,Yuki, S., and Kogure, K. Strong attenuation of ischemic and postischemic brain edema in rats by a novel free radical scavenger. Stroke 19, 480-485 (1988). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | 22 |
| 纯度 | ≥98% |
| 计算分子量 | 174.2 |
| 分子式 | C10H10N2O |
| CAS号 | 89-25-8 |
| 稳定性 | ≥ 2 years |
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