| 货号 | 13144-1mg |
| 描述 | Anacardic acid, isolated from cashew shells or several other medicinal plants, is the general name given to a family of four different 6-alkyl salicyclic acids having varying degrees of unsaturation in the 15-carbon alkyl chain.1 These compounds are associated with anti-inflammatory, anti-tumor, molluscicidal, and anti-microbial activity. Literature frequently sites and gives the name anacardic acid to the completely-saturated compound (6-pentadecyl salicylic acid). Anacardic acid inhibits the histone acetyltransferase (HAT) activity of the transcription co-activators p300 and p300/CREB-binding protein-associated factor (PCAF) with IC50 values of 8.5 and 5 µM, respectively.2 At 25 µmol/L, anacardic acid suppresses NF-κB activation, inhibits IκB-α phosphorylation, and prohibits p65 nuclear translocation in KBM-5 cells.3 |
| 别名 | 6-pentadecyl Salicylic Acid; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Satoh, M.,Takeuchi, N.,Fujita, T., et al. Synthesis of anacardic acids utilizing an annelation reaction of isoxazoles with ethyl acetoacetate. Chemical & Pharmaceutical Bulletin 46(10), 1501-1505 (1998). 2.Balasubramanyam, K.,Swaminathan, V.,Ranganathan, A., et al. Small molecule modulators of histone acetyltransferase p300. The Journal of Biological Chemisty 278(21), 19134-19140 (2003). 3.Sung, B.,Pandey, M.K.,Ahn, K.S., et al. Anacardic acid (6-nonadecyl salicylic acid), an inhibitor of histone acetyltransferase, suppresses expression of nuclear factor-κB-regulated gene products involved in cell survival, proliferation, invasion, and inflammation through inhibition of the inhibitory subunit of nuclear factor-κBα kinase, leading to potentiation of apoptosis. Blood 111, 4880-4891 (2008). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 348.5 |
| 分子式 | C22H36O3 |
| CAS号 | 16611-84-0 |
| 稳定性 | ≥ 2 years |
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