| 货号 | 13034-1mg |
| 描述 | The dual specific threonine/tyrosine kinase MEK is a key component of the RAS/RAF/MEK/ERK signaling pathway that is frequently activated in human tumors.1,2 PD 0325901 is a potent MEK inhibitor that suppresses phosphorylation of ERK in mouse colon 26 tumors with an IC50 value of 0.33 nM.3 Suppression of ERK activation with 1 µM PD 0325901 combined with 3 µM CHIR99021 (a glycogen synthase kinase 3 inhibitor) prevents cell differentiation and sustains self renewal of mouse embryonic stem cells for at least eight passages.4 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Vojtek, A.B., and Der, C.J. Increasing complexity of the Ras signaling pathway. The Journal of Biological Chemisty 273, 19925-19928 (1998). 2.Dorsam, R.T., and Gutkind, J.S. G-protein-coupled receptors and cancer. Nature Reviews.Cancer 7, 79-94 (2007). 3.Barret, S.D.,Bridges, A.J.,Dudley, D.T., et al. The discovery of the benzhydroxamate MEK inhibitors CI-1040 and PD 0325901. Bioorganic & Medicinal Chemistry Letters 18, 6501-6504 (2008). 4.Ying, Q.L.,Wray, J.,Nichols, J., et al. The ground state of embryonic stem cell self-renewal. Nature 453, 519-524 (2008). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 482.2 |
| 分子式 | C16H14F3IN2O4 |
| CAS号 | 391210-10-9 |
| 稳定性 | ≥ 2 years |
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