| 货号 | 11909-1mg |
| 描述 | FPS-ZM1 is a high-affinity inhibitor of the receptor for advanced glycation end products (RAGE; Ki = 25 nM).1 It blocks the binding of amyloid β (Aβ) protein to RAGE and inhibits Aβ40- and Aβ42-induced cellular stress in RAGE-expressing cells.1 FPS-ZM1 is functional in mice when administered intraperitoneally and penetrates the blood-brain barrier (BBB), inhibiting β-secretase activity, Aβ production, microglia activation, and neuroinflammation.1,2 FPS-ZM1 is used to elucidate the role of RAGE-mediated signaling in diverse physiological processes in vivo, including cancer tumor growth, angiogenesis, and metastasis, as well as BBB damage, edema, and inflammation after intracerebral hemorrhage.3,4 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Deane, R.,Singh, I.,Sagare, A.P., et al. A multimodal RAGE-specific inhibitor reduces amyloid β-mediated brain disorder in a mouse model of Alzheimer disease. J. Clin. Invest. 122(4), 1377-1392 (2012). 2.Hong, Y.,Shen, C.,Yin, Q., et al. Effects of RAGE-specific inhibitor FPS-ZM1 on amyloid-β metabolism and AGEs-induced inflammation and oxidative stress in rat hippocampus. Neurochem. Res. 41(5), 1192-1199 (2016). 3.Kwak, T.,Drews-Elger, K.,Ergonul, A., et al. Targeting of RAGE-ligand signaling impairs breast cancer cell invasion and metastasis. Oncogene Epub ahead of print, (2016). 4.Yang, F.,Wang, Z.,Zhang, J.H., et al. Receptor for advanced glycation end-product antagonist reduces blood-brain barrier damage after intracerebral hemorrhage. Stroke 46(5), 1328-1336 (2015). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 327.9 |
| 分子式 | C20H22ClNO |
| 稳定性 | ≥ 2 years |
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