| 货号 | 11681-500mg |
| 描述 | α-Asarone is a component of certain essential oils used in traditional Chinese herbal medicine. Although carcinogenic, α-asarone has been shown to be neuroprotective and radioprotective in mice when given at 50 mg/kg.1,2,3 It also lowers serum cholesterol in rats, specifically reducing LDL-cholesterol levels and cholesterol saturation index, by directly inhibiting HMG-CoA reductase (IC50 = 3 mM).4,5 α-Asarone also directly interacts with and inhibits certain isoforms of cytochrome P450 (IC50 = 55.2 and 65.2 μg/ml for CYP2D6 and CYP3A4, respectively).6 |
| 别名 | trans-Asarone; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Limón, I.D.,Mendieta, L.,Díaz, A., et al. Neuroprotective effect of alpha-asarone on spatial memory and nitric oxide levels in rats injected with amyloid-β(25-35). Neuroscience Letters 453(2), 98-103 (2009). 2.Sandeep, D., and Nair, C.K. Radioprotection by α-asarone: Prevention of genotoxicity and hematopoietic injury in mammalian organism. Mutation Research 722(1), 62-68 (2011). 3.Zuo, H.L.,Yang, F.Q.,Zhang, X.M., et al. Separation of cis- and trans-Asarone from Acorus tatarinowii by preparative gas chromatography. J.Anal.Methods Chem. 2012, 1-5 (2012). 4.Rodríguez-Páez, L.,Juárez-Sanchez, M.,Antúnez-Solís, J., et al. α-Asarone inhibits HMG-CoA reductase, lowers serum LDL-cholesterol levels and reduces biliary CSI in hypercholesterolemic rats. Phytomedicine 10(5), 397-404 (2003). 5.Antunez-Solis, J.,Hernández-Derramadero, F.,Aquino-Vega, M., et al. 2,4,5-trimethoxycinnamic acid: The major metabolite of α-asarone, retains most of the pharmacological properties of α-asarone. Journal of Enzyme Inhibition and Medicinal Chemistry 24(3), 903-909 (2009). 6.Pandit, S.,Mukherjee, P.K.,Ponnusankar, S., et al. Metabolism mediated interaction of α-asarone and Acorus calamus with CYP3A4 and CYP2D6. Fitoterapia 82(3), 369-374 (2011). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 208.3 |
| 分子式 | C12H16O3 |
| CAS号 | 2883-98-9 |
| 稳定性 | ≥ 2 years |
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