Forskolin
货号：
11018-1mg 基本售价：
280.0 元 规格：
1 mg
产品信息
概述| 货号 | 11018-1mg |
| 描述 | Cyclic AMP (cAMP) is an important signal carrier necessary for the proper biological response of cells to hormones, neurotransmitters, and other extracellular signals. Forskolin is a naturally occurring diterpene that is produced by the Indian Coleus plant (C. forskohlii).1 It directly activates adenylyl cyclase through its catalytic subunit and is commonly used to raise levels of cAMP in a wide variety of intact cells and tissue preparations.2 Forskolin binds to adenylyl cyclase in membranes from stably transfected Sf9 cells expressing type 1 adenylyl cyclase with an IC50 value of 41 nM and demonstrates an EC50 value of 0.5 μM in an activation assay assessing formation of cAMP from ATP.1 Forskolin also interacts with glucose transporters and certain ion channels and has been used for examining adenylyl cyclase expression, regulation, and G protein signaling.2 |
| 别名 | Coleonol;HL 362;L 75-1362B;NSC 357088;NSC 375489; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Robbins, J.D.,Boring, D.L.,Tang, W.J., et al. Forskolin carbamates: Binding and activation studies with type I adenylyl cyclase. Journal of Medicinal Chemistry 39, 2745-2752 (1996).
2.Insel, P.A. and Ostrom, R.S. Forskolin as a tool for examining adenylyl cyclase expression, regulation, and G protein signaling. Cell Mol.Neurobiol. 23(3), 305-314 (2003).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 410.5 |
| 分子式 | C22H34O7 |
| CAS号 | 66575-29-9 |
| 稳定性 | ≥ 2 years |
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