| 货号 | 10397-500mg |
| 描述 | The poly(ADP-ribose) polymerases (PARPs) comprise a family of enzymes which post-translationally modify proteins by poly(ADP-ribosyl)ation. Since some PARPs are activated by DNA strand breaks, PARP signaling has roles in DNA repair, apoptosis, inflammation, and other cellular responses. 3-amino Benzamide is an inhibitor of PARPs (Ki = 1.8 μM).1 Through its effects on PARPs, 3-amino benzamide causes telomere shortening and stimulates angiogenesis.2,3 It has PARP-mediated actions in such diverse diseases as atherosclerosis, neurogenesis, and cancer.4,5,6 |
| 别名 | 3-(Aminocarbonyl) Aniline;3-Carboxamidoaniline; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Purnell, M.R. and Whish, W.J.D. Novel inhibitors of poly(ADP-ribose) synthetase. Biochemistry Journal 185, 775-777 (1980). 2.Beneke, S.,Cohausz, O.,Malanga, M., et al. Rapid regulation of telomere length is mediated by poly(ADP-ribose) polymerase-1. Nucleic Acids Research 36(19), 6309-6317 (2008). 3.Caldini, R.,Fanti, E.,Magnelli, L., et al. Low doses of 3-aminobenzamide, a poly(ADP-ribose) polymerase inhibitor, stimulate angiogenesis by regulating expression of urokinase type plasminogen activator and matrix metalloprotease 2. Vasc.Cell 3(1), 1-10 (2011). 4.Xie, J.j.,Yu, X.,Liao, Y.h., et al. Poly (ADP-ribose) polymerase inhibition attenuates atherosclerotic plaque development in ApoE-/- mice with hyperhomocysteinemia. Journal of Atherosclerosis and Thrombosis 16(5), 641-653 (2009). 5.Madinier, A.,Bertrand, N.,Mossiat, C., et al. Microglial involvement in neuroplastic changes following focal brain ischemia in rats. PLoS One 4(12), 1-12 (2009). 6.Bey, E.A.,Bentle, M.S.,Reinicke, K.E., et al. An NQO1- and PARP-1-mediated cell death pathway induced in non-small-cell lung cancer cells by β-lapachone. Proceedings of the National Academy of Sciences of the United States of America 104(28), 11832-11837 (2007). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 136.2 |
| 分子式 | C7H8N2O |
| CAS号 | 3544-24-9 |
| 稳定性 | ≥ 2 years |
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