Mevastatin
货号：
10010340-5mg 基本售价：
280.0 元 规格：
5 mg
产品信息
概述| 货号 | 10010340-5mg |
| 描述 | HMG-CoA reductase is the rate-limiting enzyme in the cholesterol biosynthetic pathway and the target of the “statin” class of cholesterol-lowering drugs.1 Mevastatin is a HMG-CoA reductase inhibitor that was initially isolated from the mold Pythium ultimum. It inhibits HMG-CoA reductase in a reversible and competitive manner with a Ki value of 1 nM for the open ring acid form of the molecule.2 During a 24 week study period, a dose of 30 mg/day mevastatin reduced plasma LDL-cholesterol approximately 29% in patients with familial hypercholesterolemia.2 Mevastatin also suppresses TNF-induced NF-κB activation (IC50 = ~17 µM), which potentiates apoptosis in human myeloid leukemia cells and thus, may be useful in treating cancer.3 |
| 别名 | Compactin;CS 500;L 637312;ML 236B;NSC 281245;Statin I; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Tobert, J.A. Lovastatin and beyond: The history of the HMG-CoA reductase inhibitors. Nature Reviews.Drug Discovery 2(7), 517-526 (2003).
2.Endo, A. The discovery and development of HMG-CoA reductase inhibitors. Journal of Lipid Research 33, 1569-1582 (1992).
3.Ahn, K.S.,Sethi, G. and Aggarwal, B.B. Reversal of chemoresistance and enhancement of apoptosis by statins through down-regulation of the NF-κB pathway. Biochemical Pharmacology 75(4), 907-913 (2008).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 390.5 |
| 分子式 | C23H34O5 |
| CAS号 | 73573-88-3 |
| 稳定性 | ≥ 2 years |
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