Lavendustin C
货号：
10010329-1mg 基本售价：
280.0 元 规格：
1 mg
产品信息
概述| 货号 | 10010329-1mg |
| 描述 | HDBA, a derivative of a Streptomyces griseolavendus butyl acetate extract, is a potent inhibitor of epidermal growth factor (EGF) receptor-associated tyrosine kinase with an IC50 value of 0.012 µM.1 HDBA also inhibits pp60c-src(+) kinase and Ca2+ calmodulin-dependent kinase II with IC50 values of 0.5 and 0.2 µM, respectively.2 At a concentration of 10-150 µM, HDBA inhibits tyrosine kinase-associated neutrophil degranulation and superoxide generation.3 |
| 别名 | HDBA;NSC 666251; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Onoda, T.,Iinuma, H.,Sasaki, Y., et al. Isolation of a novel tyrosine kinase inhibitor, lavendustin A, from Streptomyces griseolavendus. Journal of Natural Products 52(6), 1252-1257 (1989).
2.ODell, T.J.,Kandel, E.R., and Grant, S.G.N. Long-term potentiation in the hippocampus is blocked by tyrosine kinase inhibitors. Nature 353, 558-560 (1991).
3.Burt, H.M.,Jackson, J.K., and Salari, H. Inhibition of crystal-induced neutrophil activation by a protein tyrosine kinase inhibitor. Journal of Leukocyte Biology 55, 112-119 (1994).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 275.3 |
| 分子式 | C14H13NO5 |
| CAS号 | 125697-93-0 |
| 稳定性 | ≥ 2 years |
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