CAY10561
货号：
10010043-500ug 基本售价：
280.0 元 规格：
500 ug
产品信息
概述| 货号 | 10010043-500ug |
| 描述 | The extracellular signal-regulated kinase (ERK) signal transduction pathway regulates a diverse array of cellular processes. These processes include cell survival, proliferation, motility, and differentiation and are constitutively activated in cancers involving lung, colon, pancreas, kidney, and ovary.1 CAY10561 is a potent, ATP-competitive inhibitor of ERK2 (Ki = 2 nM).2 This compound is highly selective for ERK2 compared to other kinases such as PKA (Ki = 0.39 µM) and JNK3 (Ki = 4 µM).2 CAY10561 inhibits proliferation of COLO 205 cells with an IC50 value of 0.54 µM.2 |
| 别名 | Pyrazolylpyrrole ERK Inhibitor; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Junttila, M.R.,Li, S.P., and Westermarck, J. Phosphatase-mediated crosstalk between MAPK signaling pathways in the regulation of cell survival. The FASEB Journal 22, 1-12 (2008).
2.Aronov, A.M.,Baker, C.,Bemis, G.W., et al. Flipped out: Structure-guided of selective pyrazolylpyrrole ERK inhibitors. Journal of Medicinal Chemistry 50, 1280-1287 (2007).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 459.3 |
| 分子式 | C22H17Cl2FN4O2 |
| CAS号 | 933786-58-4 |
| 稳定性 | ≥ 2 years |
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