| 货号 | 10007902-1mg |
| 描述 | Sphingosine is an amino alcohol most commonly characterized by an 18-carbon unsaturated hydrocarbon chain D-erythro-Sphingosine C-18 (Item No. 10007907). However, the hydrocarbon chain length of sphingosine, and the related dihydrosphingosine, can vary from 12-26 carbons in mammalian tissues.1,2D-erythro-Sphingosine C-17 is a naturally-occurring but uncommon form of sphingosine, accounting for approximately 13% of the sphingosine in human skin.1 It can be phosphorylated by sphingosine kinases to produce C-17 sphingosine-1-phosphate.3 More commonly, sphingosine C-17 is used as an internal standard in the analysis of sphingoid compounds by chromatographic or spectrometric methods.4,5,6 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Stewart, M.E., and Downing, D.T. Free sphingosines of human skin include 6-hydroxysphingosine and unusually long-chain dihydrosphingosines. Journal of Investigative Dermatology 105, 613-618 (1995). 2.Pruett, S.T.,Bushnev, A.,Hagedorn, K., et al. Biodiversity of sphingoid bases ("sphingosines") and related amino alcohols. Journal of Lipid Research 49, 1621-1639 (2008). 3.Hong, J.H.,Youm, J.K.,Kwon, M.J., et al. K6PC-5, a direct activator of sphingosine kinase 1, promotes epidermal differentiation through intracellular Ca2+ signaling. Journal of Investigative Dermatology 128, 2166-2178 (2008). 4.Choi, C.H.,Jeong, J.S.,Yoo, B.i., et al. Sphingosine 1-phosphate and sphingosine kinase activity during chicken embryonic development. Archives of Pharmacal Research 30(4), 502-506 (2007). 5.Paugh, S.W.,Paugh, B.S.,Rahmani, M., et al. A selective sphingosine kinase 1 inhibitor integrates multiple molecular therapeutic targets in human leukemia. Blood 112, 1382-1391 (2008). 6.Takabe, K.,Kim, R.H.,Allegood, J.C., et al. Estradiol induces export of sphingosine 1-phosphate from breast cancer cells via ABCC1 and ABCG2. The Journal of Biological Chemisty 285(14), 10477-10486 (2010). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 285.5 |
| 分子式 | C17H35NO2 |
| CAS号 | 6918-48-5 |
| 稳定性 | ≥ 2 years |
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