(±)-2-Methyl Arachidonoyl-2-Fluoroethylamide
货号：
90055-1mg 基本售价：
266.0 元 规格：
1 mg
产品信息
概述| 货号 | 90055-1mg |
| 描述 | (±)-2-Methyl arachidonoyl-2-fluoroethylamide (2-Methyl-2-fluoro AEA) is an analog of anandamide (AEA) in which the alcohol of the ethanolamide group has been removed and replaced with a fluorine atom. This substitution confers considerably increased binding affinity for the CB1 receptor (Ki = 5.7 nM in rat brain). It also confers additional selectivity, in that binding to CB2 is decreased relative to AEA.1 However, the in vivo activity of 2-fluoro AEA is enhanced much less than the binding affinity, because the analog remains a good substrate for FAAH and is rapidly hydrolyzed by this enzyme. 2-Methyl-2-fluoro AEA is further modified by the addition of an α-methyl group at the C-2 position of arachidonic acid. This substitution confers enhanced metabolic stability. 2-Methyl-2-fluoro AEA can fully substitute for Δ9-THC in animal self-administration tests, whereas AEA and 2-fluoro AEA cannot.2 |
| 别名 | 2-methyl-2-fluoro AEA;2-Methyl-2-fluoro Anandamide;O-689; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Lin, S.,Khanolkar, A.D.,Fan, P., et al. Novel analogues of arachidonylethanolamide (anandamide): Affinities for the CB1 and CB2 cannabinoid receptors and metabolic stability. Journal of Medicinal Chemistry 41, 5353-5361 (1998).
2.Ryan, W.J.,Banner, K.,Crocker, P.J., et al. Synthesis of (+)- and (−)-2-methylarachidonyl-2-fluoroethylamide (O-689). Bioorganic & Medicinal Chemistry Letters 7, 2669-2672 (1997).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 363.6 |
| 分子式 | C23H38FNO |
| CAS号 | 166100-39-6 |
| 稳定性 | ≥ 2 years |
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