| 货号 | 70715-1mg |
| 描述 | Antagonists of the chemotactic and inflammatory lipoxygenase product leukotriene B4(LTB4) have been potential drug development targets for several years.1,2 The tetrazole LY255283 is a competitive antagonist of the BLT2 receptor. It displaces radiolabeled LTB4 from guinea pig lung membrane, with an IC50 of about 100 nM.3 LY255283 exhibits IC50 values of ~950 nM and >10 µM at human recombinant BLT2 and BLT1 receptors, respectively.4 LY255283 inhibits eosinophil chemotaxis by 80% at a concentration of 10 µM, and inhibits the binding of radiolabeled LTB4 to eosinophil membranes with an IC50 of 260 nM.1 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Richards, I.M.,Sun, F.F.,Taylor, B.M., et al. Contribution of leukotriene B4 to airway inflammation and the effect of antagonists. Annals of the New York Academy of Sciences 629, 274-287 (1991). 2.Taylor, B.M.,Crittenden, N.J.,Bruden, M.N., et al. Biological activity of leukotriene B4 analogs: Inhibition of guinea pig eosinophil migration in vitro by 2,6-disubstituted pyridine analogs U-75,302 and U-75,485. Prostaglandins 42, 211-224 (1991). 3.Silbaugh, S.A.,Stengel, P.W.,Cockerham, S.L., et al. Pulmonary actions of LY255283, a leukotriene B4 receptor antagonist. European Journal of Pharmacology 223, 57-64 (1992). 4.Yokomizo, T.,Kato, K.,Hagiya, H., et al. Hydroxyeicosanoids bind to and activate the low affinity leukotriene B4 receptor, BLT2. The Journal of Biological Chemisty 276(15), 12454-12459 (2001). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 360.5 |
| 分子式 | C19H28N4O3 |
| CAS号 | 117690-79-6 |
| 稳定性 | ≥ 1 year |
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