| 货号 | 70675-50mg |
| 描述 | Phenolic compounds, particularly flavonoids, from plant sources have long been observed to have antioxidant activity with potential benefits for human health.1,2,3trans-Resveratrol is a potent phenolic antioxidant found in grapes and red wine that also has antiproliferative and anti-inflammatory activity.4trans-Resveratrol is also a selective inhibitor of cyclooxygenase 1 (COX-1).5 It inhibits COX and peroxidase activities of COX-1 with ED50 values of 15 and 3.7 µM, respectively; with essentially no inhibition of the COX activity of COX-2. Resveratrol also activates sirtuins6 and, in C. elegans, extends lifespan.7 |
| 别名 | (E)-Resveratrol; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Frémont, L.,Belguendouz, L. and Delpal, S. Antioxidant activity of resveratrol and alcohol-free wine polyphenols related to LDL oxidation and polyunsaturated fatty acids. Life Sciences 64, 2511-2521 (1999). 2.Johnson, J.L. and Maddipati, K.R. Paradoxical effects of resveratrol on the two prostaglandin H synthases. Prostaglandins & Other Lipid Mediators 56, 131-143 (1998). 3.Rotondo, S.,Rajtar, G.,Manarini, S., et al. Effect of trans-resveratrol, a natural polyphenolic compound, on human polymorphonuclear leukocyte function. British Journal of Pharmacology 123, 1691-1699 (1998). 4.Miller, N.J. and Rice-Evans, C. Antioxidant activity of resveratrol in red wine. Clinical Chemistry 41, 1789-1789 (1995). 5.Jang, M.,Cai, L.,Udeani, G.O., et al. Cancer chemopreventive activity of resveratrol, a natural product derived from grapes. Science 275, 218-220 (1997). 6.Borra, M.T.,Smith, B.C. and Denu, J.M. Mechanism of human SIRT1 activation by resveratrol. The Journal of Biological Chemisty 280(17), 17187-17195 (2005). 7.Howitz, K.T.,Bitterman, K.J.,Cohen, H.Y., et al. Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan. Nature 425, 191-196 (2003). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 228.2 |
| 分子式 | C14H12O3 |
| CAS号 | 501-36-0 |
| 稳定性 | ≥ 1 year |
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