Indomethacin N-octyl amide
货号：
70273-1mg 基本售价：
266.0 元 规格：
1 mg
产品信息
概述| 货号 | 70273-1mg |
| 描述 | Indomethacin is a potent but non-selective inhibitor of both COX-1 and COX-2 in sheep and humans.1 Structurally, indomethacin is a substituted indole acetic acid, wherein the carboxylate can be derivitized as an ester or amide. These derivatives show enhanced selectivity for the COX-2 isoform. For example, the IC50 values of indomethacin N-octyl amide for the inhibition of ovine COX-1 and human recombinant COX-2 are 66 µM and 40 nM, respectively, making it 1,650 times more potent as an inhibitor of COX-2 than COX-1.2 While indomethacin itself has an IC50 of 0.05 µM for the inhibition of COX-2, it also inhibits COX-1 with a corresponding IC50 of 0.67 µM. |
性能| 供应商 | Cayman |
| 应用文献 |
1.Barnett, J.,Chow, J.,Ives, D., et al. Purification, characterization and selective inhibition of human prostaglandin G/H synthase 1 and 2 expressed in the baculovirus system. Biochimica et Biophysica Acta 1209, 130-139 (1994).
2.Kalgutkar, A.S.,Marnett, A.B.,Crews, B.C., et al. Ester and amide derivatives of the nonsteroidal antiinflammatory drug, indomethacin, as selective cyclooxygenase-2 inhibitors. Journal of Medicinal Chemistry 43, 2860-2870 (2000).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 469 |
| 分子式 | C27H33ClN2O3 |
| CAS号 | 282728-65-8 |
| 稳定性 | ≥ 2 years |
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