| 货号 | 360900-100ug |
| 描述 | PAF C-16-d4 contains four deuterium atoms at the 7, 7, 8, and 8 positions of the hexadecyl moiety. It is intended for use as an internal standard for the quantification of PAF C-16 by GC- or LC-mass spectrometry. PAF C-16 is a naturally occurring phospholipid produced upon stimulation through two distinct pathways known as the “remodeling” and de novopathways.1 It is a potent mediator of neutrophil migration,2 the production of reactive oxygen species,3 and IL-64 in human macrophages. It is a more potent mediator of platelet aggregation than PAF C-185. Pathological processes involving PAF include necrotizing enterocolitis,6 inflammation, asthma, and allergy.7 |
| 别名 | Platelet-activating Factor C-16-d4; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Prescott, S.M.,Zimmerman, G.A. and McIntyre, T.M. Platelet-activating factor. The Journal of Biological Chemisty 265, 17381-17384 (1990). 2.Carolan, E.J. and Casale, T.B. Degree of platelet activating factor-induced neutrophil migration is dependent upon the molecular species. Journal of Immunology 145, 2561-2565 (1990). 3.Rouis, M.,Nigon, F. and Chapman, M.J. Platelet activating factor is a potent stimulant of the production of active oxygen species by human monocyte-derived macrophages. Biochemical and Biophysical Research Communications 156, 1293-1301 (1988). 4.Thivierge, M. and Rola-Pleszczynski, M. Platelet-activating factor enhances interleukin-6 production by alveolar macrophages. Journal of Allergy and Clinical Immunology 90, 796-802 (1992). 5.Stewart, A.G. and Grigoriadis, G. Structure-activity relationships for platelet-activating factor (PAF) and analogs reveal differences between PAF receptors on platelets and macrophages. Journal of Lipid Mediators 4, 299-308 (1991). 6.Wang, H.,Tan, X.D.,Qu, X.W., et al. Platelet-activating factor (PAF) up-regulates plasma and tissue PAF-acetylhydrolase activity in the rat: Effect of cycloheximide. Pediatric Research 42, 597-603 (1997). 7.Sturk, A.,Wouter Ten Cate, J.,Hosford, D., et al. The synthesis, catabolism, and pathophysiological role of platelet-activating factor. Advances in Lipid Research 23, 219-276 (1989). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥99% deuterated forms (d1-d4) |
| 计算分子量 | 527.7 |
| 分子式 | C26H50D4NO7P |
| CAS号 | 211106-54-6 |
| 稳定性 | ≥ 1 year |
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