| 货号 | 20516-1g |
| 描述 | D-Fructose-1,6-bisphosphate is an intermediate in carbohydrate metabolism, including glycolysis and gluconeogenesis. During glycolysis, it is generated by the phosphorylation of fructose-6-phosphate by phosphofructokinase. The reverse reaction, mediated by fructose-1,6-bisphosphatase-1, is one of the rate-limiting steps in gluconeogenesis.1,2 The same reaction occurs within chloroplasts in plants as part of the reductive pentose phosphate cycle.3 Because cancer cells adopt glycolysis as a major source of metabolic energy production, this pathway has become a major target for cancer chemotherapy.4 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Marcus, F. and Hosey, M.M. Purification and properties of liver fructose 1,6-bisphosphatase from C57BL/KsJ normal and diabetic mice. The Journal of Biological Chemisty 255(6), 2481-2486 (1980). 2.Van Den Berghe, G. Disorders of gluconeogenesis. J.Inher.Metab.Dis. 19, 470-477 (1996). 3.Wolosiuk, R.A.,Ballicora, M.A. and Hagelin, K. The reductive pentose phosphate cycle for photosynthetic CO2 assimilation: Enzyme modulation. FASEB J. 7, 622-637 (1993). 4.Seo, M.,Kim, J.D.,Neau, D., et al. Structure-based development of small molecule PFKFB3 inhibitors: A framework for potential cancer therapeutic agents targeting the Warburg effect. PLoS One 6(9), 1-12 (2011). | |
| 运输条件 | Ambient in continental US; may vary elsewhere |
| 存放说明 | 22 |
| 纯度 | ≥95% |
| 计算分子量 | 550.2 |
| 分子式 | C6H11O12P2 • 3Na [8H2O] |
| CAS号 | 81028-91-3 |
| 稳定性 | ≥ 2 years |
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