Barnidipine (hydrochloride)
货号：
20448-10mg 基本售价：
266.0 元 规格：
10 mg
产品信息
概述| 货号 | 20448-10mg |
| 描述 | Barnidipine is a dihydropyridine calcium channel blocker that has an IC50 value of 0.35 nM in potassium-induced tonic contraction of pig coronary artery.1 It demonstrates antihypertensive activity by reducing peripheral vascular resistance. It decreases blood pressure in spontaneously hypertensive rats when administered orally at 1 and 3 mg/kg per day.2 Formulations containing barnidipine have been used as a treatment for hypertension. In obstructive sleep apnea patients with non-dipper pattern hypertension, barnidipine reduced mean nighttime systolic and diastolic arterial blood pressure.3 |
| 别名 | YM-09730-5; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Nakayama, K.,Kashiwabara, T.,Yamada, S., et al. Assessment in pig coronary artery of long-lasting and potent calcium antagonistic actions of the novel dihydropyridine derivative mepirodipine hydrochloride. Arzneimittelforschung 39(1), 50-55 (1989).
2.Kawashima, K.,Toda, H.,Oohata, H., et al. Antihypertensive and diuretic effects of YM-09730-5, a new calcium antagonist, in stroke-prone spontaneously hypertensive rats. Gen. Pharmacol. 22(2), 263-266 (1991).
3.Crippa, G.,Zabzuni, D.,Cassi, A., et al. Effect of bedtime dosing of barnidipine hydrochloride in non-dipper hypertensive patients with obstructive sleep apnoea not treated with continuous positive airway pressure. Eur. Rev. Med. Pharmacol. Sci. 20(2), 339-344 (2016).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 528 |
| 分子式 | C27H29N3O6 • HCl |
| CAS号 | 104757-53-1 |
| 稳定性 | ≥ 2 years |
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