| 货号 | 20303-100mg |
| 描述 | Ketotifen (fumarate) is a second generation histamine H1 receptor antagonist (IC50 = 1.3 nM) and mast cell stabilizer.1,2,3 It has been shown to inhibit the quick phase reaction in a rat antigen-induced immediate airway response model and has been studied in the clinical trials studying the treatment of irritable bowel syndrome.4,5 |
| 别名 | HC 20511; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Buckle, D.R.,Rockell, C.J.M.,Smith, H., et al. Studies on 1,2,3-triazoles. 13. (Piperazinylalkoxy) [1]benzopyrano[2,3-d]-1,2,3-triazol-9(1H)-ones with combined H1-antihistamine and mast cell stabilizing properties. J.Med.Chem. 29(11), 2262-2267 (1986). 2.Nishikawa, Y.,Shindo, T.,Ishi, K., et al. Acrylamide derivatives as antiallergic agents. III. Synthesis and structure-activity relationships of N-[4-(4-diphenylmethyl-1-piperazinyl)butyl]- and N-[4-(4-diphenylmethylene-1-piperidyl)butyl]-3-heteroarylacry lamides. Chem.Pharm.Bull.(Tokyo) 37(3), 684-687 (1989). 3.Sharif, N.A.,Xu, S.X. and Yanni, J.M. Olopatadine (AL-4943A): Ligand binding and functional studies on a novel, long acting H1-selective histamine antagonist and anti-allergic agent for use in allergic conjunctivitis. Journal of Ocular Pharmacology and Therapeutics 12(4), 401-407 (1996). 4.Miyagawa, N.,Iwasaki, H.,Kato, T., et al. Two pharmacological phases in antigen-induced immediate airway response in rats. Biological and Pharmaceutical Bullentin 32(12), 2260-2264 (2008). 5.Manabe, N.,Rao, A.S.,Wong, B.S., et al. Emerging pharmacologic therapies for irritable bowel syndrome. Curr.Gastroenterol.Rep. 12(5), 408-416 (2010). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 425.5 |
| 分子式 | C19H19NOS • C4H4O4 |
| CAS号 | 34580-14-8 |
| 稳定性 | ≥ 2 years |
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