| 货号 | 20261-5g |
| 描述 | N-Acetyl-L-cysteine (NAC) is an antioxidant and precursor of glutathione that has multiple effects in cells and animals. As an antioxidant, NAC scavenges hydrogen peroxide, hydroxyl radical, and hypochlorous acid.1,2 NAC may be deacetylated to cysteine, which can be combined with glutamate and glycine to produce reduced glutathione (Item No. 10007461), which serves to reduce hydroperoxides and detoxify xenobiotics.1,2 The free sulfhydryl group of NAC can also hydrolyze disulfide bonds of mucins and other proteins, thus facilitating clearance of mucus.3 Through these actions, NAC inhibits DNA adduct formation, limits hepatotoxic effects of acetaminophen, and provides diverse cytoprotective effects in vivo.4,1,5,2,3,6 |
| 别名 | Acetylcysteine;NSC 111180;NAC; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Gillissen, A. and Nowak, D. Characterization of N-acetylcysteine and ambroxol in anti-oxidant therapy. Respir. Res. 92(4), 609-623 (1998). 2.Kelly, G.S. Clinical applications of N-acetylcysteine. Altern. Med. Rev. 3(2), 114-127 (1998). 3.Rubin, B.K. Aerosol medications for treatment of mucus clearance disorders. Respir. Care 60(6), 825-829 (2015). 4.Cavalieri, E.L. and Rogan, E.G. Depurinating estrogen-DNA adducts, generators of cancer initiation: their minimization leads to cancer prevention. Clin. Transl. Med. 5(1), (2016). 5.Izzotti, A.,DAgostini, F.,Bagnasco, M., et al. Chemoprevention of carcinogen-DNA adducts and chronic degenerative diseases. Cancer Res. 54(7 suppl), 1994s-1998s (1994). 6.Yoon, E.,Babar, A.,Choudhary, M., et al. Acetaminophen-induced hepatotoxicity: A comprehensive update. J. Clin. Transl. Hepatol. 4(2), 131-142 (2016). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 163.2 |
| 分子式 | C5H9NO3S |
| CAS号 | 616-91-1 |
| 稳定性 | ≥ 2 years |
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