| 货号 | 19193-5g |
| 描述 | Fibrinolysis, the cleavage of fibrin by plasmin, is a normal step in the dissolution of fibrin clots after wound repair.1 Tranexamic acid is an inhibitor of fibrinolysis that blocks the interaction of plasmin with fibrin (IC50 = 3.1 µM).2,3 It is a lysine mimetic that binds the lysine binding site in plasmin. Antifibrinolytic agents have value when fibrinolytic activity is abnormally high or when coagulation is impaired.4,3 |
| 别名 | AMCA;TXA; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Okafor, O.N. and Gorog, D.A. Endogenous fibrinolysis: An important mediator of thrombus formation and cardiovascular risk. Journal of the American College of Cardiology 65(16), 1683-1699 (2015). 2.Boström, J.,Grant, J.A.,Fjellström, O., et al. Potent fibrinolysis inhibitor discovered by shape and electrostatic complementarity to the drug tranexamic acid. Journal of Medicinal Chemistry 56(8), 3273-3280 (2013). 3.Cheng, L.,Pettersen, D.,Ohlsson, B., et al. Discovery of the fibrinolysis inhibitor AZD6564, acting via interference of a protein-protein interaction. ACS Med.Chem.Lett. 5(5), 538-543 (2014). 4.Prentice, C.R.M. Basis of antifibrinolytic therapy. J.Clin.Pathol.Suppl.(R.Coll.Pathol). 14, 35-40 (1980). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | 22 |
| 纯度 | ≥95% |
| 计算分子量 | 157.2 |
| 分子式 | C8H15NO2 |
| CAS号 | 1197-18-8 |
| 稳定性 | ≥ 2 years |
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