NASPM (hydrochloride)
货号：
18453-1mg 基本售价：
266.0 元 规格：
1 mg
产品信息
概述| 货号 | 18453-1mg |
| 描述 | NASPM is a synthetic analog of Joro spider toxin that blocks GluR2-lacking, Ca2+-permeable AMPA receptors. The blocking effect of NASPM on these receptors is use and voltage-dependent. At -60 mV, NASPM can suppress current responses in kainate-induced type II neurons (which are typified by strong inward rectification and high permeability to Ca2+) with an IC50 value of 0.33 µM.1 However, at +40 mV, NASPM does not affect Ca2+-permeable AMPA receptors.1 NASPM has been shown to protect against ischemia-induced neuronal cell death by preventing influx of toxic levels of Ca2+ into injured neurons.2 This compound can be used to study the role of GluR2 subunits in calcium permeability of AMPA receptors.3,2 |
| 别名 | 1-Naphthylacetyl spermine; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Koike, M.,Iino, M. and Ozawa, S. Blocking effect of 1-naphthyl acetyl spermine on Ca(2+)-permeable AMPA receptors in cultured rat hippocampal neurons. Neuroscience Research 29(1), 27-36 (1997).
2.Oguro, K.,Oguro, N.,Kojima, T., et al. Knockdown of AMPA receptor GluR2 expression causes delayed neurodegeneration and increases damage by sublethal ischemia in hippocampal CA1 and CA3 neurons. Journal of Neuroscience 19(21), 9218-9227 (1999).
3.Dong, L.D.,Gao, F.,Wang, X.H., et al. GluA2 trafficking is involved in apoptosis of retinal ganglion cells induced by activation of EphB/EphrinB reverse signaling in a rat chronic ocular hypertension model. Journal of Neuroscience 35(13), 5409-5421 (2015).
|
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 479.3 |
| 分子式 | C22H34N4O • 3HCl |
| CAS号 | 1049731-36-3 |
| 稳定性 | ≥ 2 years |
声明| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |
