| 货号 | 17150-1mg |
| 描述 | Angiotensin II is a peptide hormone known best as a vasoconstrictor with central roles in chronic hypertension, heart failure, and stroke.1 It is an octapeptide typically generated by the removal of two residues from angiotensin I by angiotensin-converting enzyme (ACE).2 Angiotensin II is a ligand for at least two distinct receptors, AT1 and AT2, each evoking distinct signaling pathways and physiological responses.1,3 The development of antagonists for specific angiotensin II receptor subtypes represents a valuable alternative to ACE inhibitors.4 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Burnier, M. Angiotensin II type 1 receptor blockers. Circulation 103, 904-912 (2001). 2.Redelinghuys, P.,Nchinda, A.T. and Sturrock, E.D. Development of domain-selective angiotensin I-converting enzyme inhibitors. Annals of the New York Academy of Sciences 1056, 160-175 (2005). 3.Bosnyak, S.,Jones, E.S.,Christopoulos, A., et al. Relative affinity of angiotensin peptides and novel ligands at AT1 and AT2 receptors. Clin. Sci. (Lond) 121(7), 297-303 (2011). 4.Wexler, R.R.,Greenlee, W.J.,Irvin, J.D., et al. Nonpeptide angiotensin II receptor antagonists: The next generation in antihypertensive therapy. Journal of Medicinal Chemistry 39(3), 625-656 (2014). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥90% |
| 计算分子量 | 1046.2 |
| 分子式 | C50H71N13O12 |
| CAS号 | 4474-91-3 |
| 稳定性 | ≥ 2 years |
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