| 货号 | 16792-500mg |
| 描述 | Kynurenic acid is a natural metabolite of tryptophan via the kynurenine pathway. It has pronounced effects on neuronal signaling and, thus, impacts diverse neurological systems.1,2 Kynurenic acid broadly antagonizes ionotopic glutamate receptors at high micromolar to millimolar concentrations and is used to pharmacologically block the activation of these receptors in vivoorin vitro.3 In addition, it reportedly has more potent effects at glutamate receptor subunit ζ-1 (Ki = 5.4 µM), GPR35 (EC50 = 39 µM), aryl hydrocarbon receptor (EC50 = 300 nM), and neuronal acetylcholine receptor α-7 (IC50 = 7 µM).4,5,6,2 |
| 别名 | NSC 58973; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Schwarcz, R.,Bruno, J.P.,Muchowski, P.J., et al. Kynurenines in the mammalian brain: When physiology meets pathology. Nature Reviews.Neuroscience 13(7), 465-477 (2012). 2.Turski, M.P.,Turska, M.,Paluszkiewicz, P., et al. Kynurenic acid in the digestive system-new facts, new challenges. Int.J.Tryptophan Res. 6, 47-55 (2013). 3.Albuquerque, E.X. and Schwarcz, R. Kynurenic acid as an antagonist of α7 nicotinic acetylcholine receptors in the brain: Facts and challenges. Biochemical Pharmacology 85(8), 1027-1032 (2013). 4.McQuaid, L.A.,Smith, E.C.,Lodge, D., et al. 3-Phenyl-4-hydroxyquinolin-2(1H)-ones: Potent and selective antagonists at the strychnine-insensitive glycine site on the N-methyl-D-aspartate receptor complex. Journal of Medicinal Chemistry 35(18), 3423-3425 (1992). 5.Wang, J.,Simonavicius, N.,Wu, X., et al. Kynurenic acid as a ligand for orphan G protein-coupled receptor GPR35. The Journal of Biological Chemisty 281(31), 22021-22028 (2006). 6.Funke, M.,Thimm, D.,Schiedel, A.C., et al. 8-Benzamidochromen-4-one-2-carboxylic acids: Potent and selective agonists for the orphan G protein-coupled receptor GPR35. Journal of Medicinal Chemistry 56(12), 5182-5197 (2013). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 189.2 |
| 分子式 | C10H7NO3 • XH2O |
| CAS号 | 345909-35-5 |
| 稳定性 | ≥ 2 years |
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