| 货号 | 16151-1g |
| 描述 | O-Phospho-L-Serine is an agonist of the group III metabotropic glutamate receptors mGluR4a and mGluR6 (EC50s = 2-5 µM).1,2 It mimics the phosphatidylserine head group and has been shown to inhibit the proliferation of microglia and to enhance neuronal differentiation of progenitor cells.3,4,5 |
| 别名 | Dexfosfoserine;L-Serine-O-Phosphate;L-SOP; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Eriksen, L. and Thomsen, C. [3H]-L-2-amino-4-phosphonobutyrate labels a metabotropic glutamate receptor, mGluR4a. British Journal of Pharmacology 116(8), 3279-3287 (1995). 2.Conn, P.J. and Pin, J.P. Pharmacology and functions of metabotropic glutamate receptors. Annual Reviews of Pharmacology and Toxicology 37, 205-237 (1997). 3.Witting, A.,Müller, P.,Herrmann, A., et al. Phagocytic clearance of apoptotic neurons by microglia/brain macrophages in vitro: Involvement of lectin-, integrin-, and phosphatidylserine-mediated recognition. Journal of Neurochemistry 75(3), 1060-1070 (2000). 4.Bailey, T.J.,Fossum, S.L.,Fimbel, S.M., et al. The inhibitor of phagocytosis, O-phospho-L-serine, suppresses Müller glia proliferation and cone cell regeneration in the light-damaged zebrafish retina. Experimental Eye Research 91(5), 601-612 (2010). 5.Saxe, J.P.,Wu, H.,Kelly, T.K., et al. A phenotypic small molecule screen identifies an orphan ligand-receptor pair that regulates neural stem cell differentiation. Chemistry & Biology 14(9), 1019-1030 (2007). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 185.1 |
| 分子式 | C3H8NO6P |
| CAS号 | 407-41-0 |
| 稳定性 | ≥ 2 years |
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