| 货号 | 14337-25mg |
| 描述 | L-Mimosine is a non-protein amino acid that can be isolated from certain plants and fungi. It chelates iron and copper and has been shown to reduce iron overload in animal models.1,2 L-Mimosine inhibits certain enzymes that contain iron or copper, including arginase (IC50 = 3.7 µM), polyphenoloxidase, and dopamine hydroxylase.2,3,4 It also inhibits the iron-containing enzyme deoxyhypusine hydroxlase, preventing the synthesis of the eukaryotic initiation factor 5A and blocking cell cycling.5 |
| 别名 | Leucenol;NSC 69188; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Kontoghiorghe, C.N.,Kolnagou, A. and Kontoghiorghes, G.J. Phytochelators Intended for Clinical Use in Iron Overload, Other Diseases of Iron Imbalance and Free Radical Pathology. Molecules 20(11), 20841-20872 (2015). 2.Nirmal, N.P. and Benjakul, S. Inhibitory effect of mimosine on polyphenoloxidase from cephalothoraxes of Pacific white shrimp (Litopenaeus vannamei). J.Agric.Food Chem 59(18), 10256-10260 (2011). 3.Ahmad, V.U.,Ullah, F.,Hussain, J., et al. Tyrosinase inhibitors from Rhododendron collettianum and their structure-activity relationship (SAR) studies. Chem.Pharm.Bull.(Tokyo) 52(12), 1458-1461 (2004). 4.Hashiguchi, H. and Takahashi, H. Inhibition of two copper-containing enzymes, tyrosinase and dopamine beta-hydroxylase, by L-mimosine. Mol.Pharmacol. 13(2), 362-367 (1977). 5.Hanauske-Abel, H.M.,Park, M.H.,Hanauske, A.R., et al. Inhibition of the G1-S transition of the cell cycle by inhibitors of deoxyhypusine hydroxylation. Biochim.Biophys.Acta. 1221(2), (1994). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 198.2 |
| 分子式 | C8H10N2O4 |
| CAS号 | 500-44-7 |
| 稳定性 | ≥ 2 years |
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