| 货号 | 13121-50g |
| 描述 | Sodium butyrate is a short chain fatty acid that has effects at the molecular, cellular, and tissue level. It has long been known as an inhibitor of histone deacetylases (HDACs).1,2 In cells, this alters the expression of a select group of genes containing butyrate response elements and may also involve Sp1/Sp3 binding sites.3 Sodium butyrate also induces growth arrest, differentiation and apoptosis in cancer cells, primarily through its effects on HDAC activity.4 In addition, it suppresses inflammation, in part by reducing the expression of pro-inflammatory cytokines, including interferon-γ, interleukin (IL)-6, and IL-1β.5 |
| 别名 | Butyric Acid; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Boffa, L.C.,Vidali, G.,Mann, R.S., et al. Suppression of histone deacetylation in vivo and in vitro by sodium butyrate. The Journal of Biological Chemisty 253(10), 3364-3366 (1978). 2.Sealy, L. and Chalkley, R. The effect of sodium butyrate on histone modification. Cell 14, 115-121 (1978). 3.Davie, J.R. Inhibition of histone deacetylase activity by butyrate. Journal of Nutrition 133, 2485-2493 (2003). 4.Monneret, C. Inhibition of histone deacetylase activity by butyrate. European Journal of Medicinal Chemistry 40, 1-13 (2005). 5.Joseph, J.,Mudduluru, G.,Antony, S., et al. Expression profiling of sodium butyrate (NaB)-treated cells: identification of regulation of genes related to cytokine signaling and cancer metastasis by NaB. Oncogene 23, 6304-6315 (2004). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | 22 |
| 纯度 | ≥95% (NMR) |
| 计算分子量 | 110.1 |
| 分子式 | C4H7O2 • Na |
| CAS号 | 156-54-7 |
| 稳定性 | ≥ 2 years |
| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |