| 货号 | 11847-5g |
| 描述 | Glycyrrhizic acid is a natural triterpenoid saponin that can be isolated from the root of licorice. It is an agonist of the human sweet taste receptor and is used as a flavorant.1 Glycyrrhizic acid has diverse cellular effects at low doses, including antioxidant, anti-inflammatory, antimicrobial, and antiviral actions.2,3,4 Presumably through its role as an antioxidant, glycyrrhizic acid alters signaling through a variety of signaling pathways, impacting pathologies such as metabolic syndrome, fibrosis, and ultraviolet-B-induced skin damage in cellular and animal models.5,6,7 |
| 别名 | Ammonium Glycyrrhizinate;Glycyrrhizin;Glycyrrhizinate;NSC 2800;NSC 35348; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Ohtsu, Y.,Nakagawa, Y.,Nagasawa, M., et al. Diverse signaling systems activated by the sweet taste receptor in human GLP-1-secreting cells. Molecular and Cellular Endocrinology 394(1-2), 70-79 (2014). 2.Ming, L.J., and Yin, A.C. Therapeutic effects of glycyrrhizic acid. Nat.Prod.Commun. 8(3), 415-418 (2013). 3.Wang, L.,Yang, R.,Yuan, B., et al. The antiviral and antimicrobial activities of licorice, a widely-used Chinese herb. Acta.Pharmac.Sin.B 5(4), 310-315 (2015). 4.Lee, K.J.,Oh, Y.C.,Cho, W.K., et al. Antioxidant and anti-inflammatory activity determination of one hundred kinds of pure chemical compounds using offline and online screening HPLC assay. Evidence-Based Complementary and alternative Medicine (2015). 5.Afnan, Q.,Kaiser, P.J.,Rafig, R.A., et al. Glycyrrhizic acid prevents ultraviolet-B-induced photodamage: a role for mitogen-activated protein kinases, nuclear factor kappa B and mitochondrial apoptotic pathway. Experimental Dermatology 25(6), 440-446 (2016). 6.Cheng, H.S.,Kong, J.M.,Ng, A.X., et al. Novel inhibitory effects of glycyrrhizic acid on the accumulation of advanced glycation end product and its receptor expression. Nat.Prod.Bioprospect. 4(6), 325-333 (2014). 7.Zhou, Y.,Tong, X.,Ren, S., et al. Synergistic anti-liver fibrosis actions of total astragalus saponins and glycyrrhizic acid via TGF-β1/Smads signaling pathway modulation. Journal of Ethnopharmacology 190, 83-90 (2016). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | 22 |
| 纯度 | ≥80% |
| 计算分子量 | 840 |
| 分子式 | C42H62O16 • NH3 |
| CAS号 | 53956-04-0 |
| 稳定性 | ≥ 2 years |
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