6α-Methylprednisolone 21-hemisuccinate
货号：
11800-10mg 基本售价：
266.0 元 规格：
10 mg
产品信息
概述| 货号 | 11800-10mg |
| 描述 | Methylprednisolone is a synthetic glucocorticoid that has anti-inflammatory and immunosuppressant effects through the glucocorticoid receptor.1 The methyl group reduces specific binding to corticosteroid-binding globulin, which may allow better tissue penetration, compared to that of prednisolone.1 6α-Methylprednisolone 21-hemisuccinate is a prodrug for methylprednisolone.2 This compound has superior water solubility compared to the active glucocorticoid.3 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Brownie, A.C. The metabolism of adrenal cortical steroids. The Adrenal Gland 2, 209-225 (1992).
2.Vree, T.B.,Lagerwerf, A.J.,Verwey-van Wissen, C.P., et al. High-performance liquid chromatography analysis, preliminary pharmacokinetics, metabolism and renal excretion of methylprednisolone with its C6 and C20 hydroxy metabolites in multiple sclerosis patients receiving high-dose pulse therapy. Journal of Chromatography B 732, 337-348 (1999).
3.Rao, V.M.,Nerurkar, M.,Pinnamaneni, S., et al. Co-solubilization of poorly soluble drugs by micellization and complexation. International Journal of Pharmacy 319, 98-106 (2006).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 474.6 |
| 分子式 | C26H34O8 |
| CAS号 | 2921-57-5 |
| 稳定性 | ≥ 2 years |
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