| 货号 | 11214-1mg |
| 描述 | Forskolin (Item No. 11018) is a potent activator of adenylyl cyclase, but it is sparingly soluble in aqueous solutions. NKH477 is a water-soluble analog of forskolin which has both inotropic and vasodilator effects when administered intravenously.1,2,3 Like forskolin, NKH477 activates adenylyl cyclases without altering the activity of phosphodiesterases or sodium/potassium ATPases.1 This compound stimulates cardiac (type V) adenylyl cyclase more potently than other isoforms.4 NKH477 relaxes guinea pig tracheal smooth muscle precontracted with histamine with an EC50 value of 32.6 nM.3 |
| 别名 | Adehl;Colforsin Dapropate;Colforsin Daropate; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Hosono, M.,Takahira, T.,Fujita, A., et al. Cardiovascular and adenylate cyclase stimulant properties of NKH477, a novel water-soluble forskolin derivative. Journal of Cardiovascular Pharmacology 19, 625-634 (1992). 2.Sanbe, A., and Takeo, S. Effects of NKH477, a water-soluble forskolin derivative, on cardiac function in rats with chronic heart failure after myocardial infarction. Journal of Pharmacology and Experimental Therapeutics 274, 120-126 (1995). 3.Satake, K.,Takagi, K.,Kodama, I., et al. Relaxant effects of NKH477, a new water-soluble forskolin derivative, on guinea-pig tracheal smooth muscle: The role of Ca2+-activated K+ channels. British Journal of Pharmacology 123, 753-761 (1998). 4.Toya, Y.,Schwencke, C., and Ishikawa, Y. Forskolin derivatives with increased selectivity for cardiac adenylyl cyclase. Journal of Molecular and Cellular Cardiology 30, 97-108 (1998). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 546.1 |
| 分子式 | C27H43NO8 • HCl |
| CAS号 | 138605-00-2 |
| 稳定性 | ≥ 2 years |
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