| 货号 | 10024-100g |
| 描述 | Acetaminophen is an analgesic and antipyretic compound. Unlike many NSAIDs, which inhibit both COX-1 and COX-2, early studies suggested that acetaminophen is a poor inhibitor of both isoforms.1,2 However, a more recent study indicates that this compound inhibits COX-2 activity by more than 80%, albeit at relatively high doses, while it is less effective against COX-1.3 Acetaminophen is enzymatically and non-enzymatically converted to several reactive metabolites that contribute to adverse or indirect effects, including liver injury.4,5,6 Acetaminophen is reportedly used a cutting agent in heroin.7 |
| 别名 | 4-Acetamidophenol;APAP;4-Hydroxyacetanilide;NSC 3991;NSC 109028;Paracetamol; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Mitchell, J.A.,Akarasereenont, P.,Thiemermann, C., et al. Selectivity of nonsteroidal antiinflammatory drugs as inhibitors of constitutive and inducible cyclooxygenase. Proceedings of the National Academy of Sciences of the United States of America 90, 11693-11697 (1993). 2.Warner, T.D.,Giuliano, F.,Vojnovic, I., et al. Nonsteroid drug selectivities for cyclo-oxygenase-1 rather than cyclo-oxygenase-2 are associated with human gastrointestinal toxicity: A full in vitro analysis. Proceedings of the National Academy of Sciences of the United States of America 96(13), 7563-7568 (1999). 3.Hinz, B.,Cheremina, O., and Brune, K. Acetaminophen (paracetamol) is a selective cyclooxygenase-2- inhibitor in man. FASEB J. 22(2), 383-390 (2007). 4.Hinson, J.A. Reactive metabolites of phenacetin and acetaminophen: A review. Environ. Health Perspect. 49, 71-79 (1983). 5.Högestätt, E.D.,Jönsson, B.A.G.,Ermund, A., et al. Conversion of acetaminophen to the biactive N-acylphenolamine AM404 via fatty acid amide hydrolase-dependent arachidonic acid conjugation in the nervous system. J. Biol. Chem. 280(36), 31405-31412 (2005). 6.Han, D.,Dara, L.,Win, S., et al. Regulation of drug-induced liver injury by signal transduction pathways: Critical role of mitochondria. Trends Pharamacol.Sci. 34(4), 243-253 (2013). 7.Broséus, J.,Gentile, N., and Esseiva, P. The cutting of cocaine and heroin: A critical review. Forensic Sci. Int. 262, 73-83 (2016). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 151.2 |
| 分子式 | C8H9NO2 |
| CAS号 | 103-90-2 |
| 稳定性 | ≥ 2 years |
| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |