| 货号 | 62530-1mg |
| 描述 | Production of ceramide occurs upon hydrolysis of sphingomyelin by a specific isoform of PLC, appropriately named sphingomyelinase.1 Nervonic ceramide (C24:1) is one of the most abundant naturally occurring ceramides.2,3,4 Ceramides mediate many diverse biological activities, as has been demonstrated in studies utilizing cell-permeable ceramide analogs. A few of the processes regulated by ceramides include apoptosis, cell differentiation, proliferation of smooth muscle cells, and inhibition of the mitochondrial respiratory chain.5,6,7 |
| 别名 | C24:1 Ceramide (d18:1/24:1(15Z));N-nervonoyl-D-erythro-sphingosine; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Perry, D.K.,Obeid, L.M., and Hannun, Y.A. Ceramide and regulation of apoptosis and the stress response. Trends in Cardiovascular Medicine 6, 158-162 (1996). 2.Gu, Q.,Kerwin, J.L.,Watts, J.D., et al. Ceramide profiling of complex lipid mixtures by electrospray ionization mass spectrometry. Analytical Biochemistry 244, 347-356 (1997). 3.Clayton, R.B.,Cooper, J.M.,Curstedt, T., et al. Stimulation of erythroblast maturation in vitro by sphingolipids. Journal of Lipid Research 15, 557-562 (1974). 4.Krivit, W., and Hammarström, S. Identification and quantitation of free ceramides in human platelets. Journal of Lipid Research 13, 525-530 (1972). 5.Testi, R. Sphingomyelin breakdown and cell fate. Trends Biochem. Sci. 21(12), 468-471 (1996). 6.Augé, N.,Andrieu, N.,Nègre-Salvayre, A., et al. The sphingomyelin-ceramide signaling pathway is involved in oxidized low density lipoprotein-induced cell proliferation. The Journal of Biological Chemisty 271(32), 19251-19255 (1996). 7.Gudz, T.I.,Tserng, K.Y., and Hoppel, C.L. Direct inhibition of mitochondrial respiratory chain complex III by cell-permeable ceramide. The Journal of Biological Chemisty 272(39), 24154-24158 (1997). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 648.1 |
| 分子式 | C42H81NO3 |
| CAS号 | 54164-50-0 |
| 稳定性 | ≥ 1 year |
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