Flufenamic Acid
货号：
21447-10g 基本售价：
252.0 元 规格：
10 g
产品信息
概述| 货号 | 21447-10g |
| 描述 | Flufenamic acid is an anthranilic acid-derived nonsteroidal anti-inflammatory drug (NSAID) thought to exert its actions by a prostanoid-independent mechanism. It inhibits fMLP- and A23187-induced Ca2+ influx in human PMNLs with IC50 values of 29 and 14 µM, respectively.1 It is also reported to inhibit cytokine-induced COX-2 expression and NFκB activation.2 Additionally, flufenamic acid has been described as an inhibitor of various ion channels, including TRP channels (TRPC3, TRPC5, TRPC6, TRPC7, TRPM2, TRPM4, and TRPM5).3 |
| 别名 | CI-440;Fluphenamic Acid;NSC 82699;NSC 219007; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Kankaanranta, H., and Moilanen, E. Flufenamic and tolfenamic acids inhibit calcium influx in human polymorphonuclear leukocytes. Molecular Pharmacology 47, 1006-1013 (1995).
2.Paik, J.H.,Ju, J.H.,Lee, J.Y., et al. Two opposing effects of non-steroidal anti-inflammatory drugs on the expression of the inducible cyclooxygenase. Mediation through different signaling pathways. The Journal of Biological Chemisty 275, 28173-28179 (2000).
3.Harteneck, C.,Frenzel, H., and Kraft, R. N-(p-amylcinnamoyl)anthranilic acid (ACA): A phospholipase A2 inhibitor and TRP channel blocker. Cardiovascular Drug Reviews 25(1), 61-75 (2007).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 281.2 |
| 分子式 | C14H10F3NO2 |
| CAS号 | 530-78-9 |
| 稳定性 | ≥ 2 years |
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