NSC 697923
货号：
15346-1mg 基本售价：
252.0 元 规格：
1 mg
产品信息
概述| 货号 | 15346-1mg |
| 描述 | NSC 697923 is a selective inhibitor of the E2 ubiquitin-conjugating enzyme Ubc13 when heterodimerized with Uev1A, blocking polyubiquitin chain formation at concentrations of 0.5 to 2 µM in vitro.1 It also inhibits NF-κB activation by PMA and other agonists, presumably through its effects on Ubc13.1 NSC 697923 blocks proliferation and induces apoptosis in diffuse large B cell lymphoma and neuroblastoma cells.1,2 It has antitumor efficacy in vivo in neuroblastoma orthotopic xenografts, when given intraperitoneally.2 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Pulvino, M.,Liang, Y.,Oleskyn, D., et al. Inhibition of proliferation and survival of diffuse large B-cell lymphoma cells by a small-molecule inhibitor of the ubiquitin-conjugating enzyme Ubc13-Uev1A. Blood 120(8), 1668-1677 (2012).
2.Cheng, J.,Fan, Y.H.,Xu, X., et al. A small-molecule inhibitor of UBE2N induces neuroblastoma cell death via activation of p53 and JNK pathways. Cell Death Dis. 5(e1079), (2014).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 267.3 |
| 分子式 | C11H9NO5S |
| CAS号 | 343351-67-7 |
| 稳定性 | ≥ 2 years |
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