| 货号 | 14714-25g |
| 描述 | Dimethyl fumarate is a lipophilic electrophile that has profound effects on oxidative and immunological pathways.1 It rapidly interacts in a Michael addition reaction with glutathione or is metabolized to monomethyl fumarate.1 Dimethyl fumarate at low micromolar levels activates the nuclear factor erythroid 2-related factor 2 (Nrf2), resulting in an antioxidant response featuring heme oxygenase-1 expression and increased glutathione levels.1 It also suppresses the expression of pro-inflammatory cytokines and inhibits angiogenesis.2,3 Through these actions dimethyl fumarate alters the course of psoriasis and may reduce inflammation related to multiple sclerosis.2,4 |
| 别名 | NSC 25942;NSC 167432;trans-Butenedioic Acid dimethyl ester; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Albrecht, P.,Bouchachia, I.,Goebels, N., et al. Effects of dimethyl fumarate on neuroprotection and immunomodulation. Journal of Neuroinflammation 9, 163 (2012). 2.Ockenfels, H.M.,Schultewolter, T.,Ockenfels, G., et al. The antipsoriatic agent dimethylfumarate immunomodulates T-cell cytokine secretion and inhibits cytokines of the psoriatic cytokine network. British Journal of Dermatology 139(3), 390-395 (1998). 3.García-Caballero, M.,Marí-Beffa, M.,Medina, M.A., et al. Dimethylfumarate inhibits angiogenesis in vitro and in vivo: A possible role for its antipsoriatic effect? Journal of Investigative Dermatology 131(6), 1347-1355 (2011). 4.Kappos, L.,Gold, R.,Miller, D.H., et al. Efficacy and safety of oral fumarate in patients with relapsing-remitting multiple sclerosis: A multicentre, randomised, double-blind, placebo-controlled phase IIb study. Lancet. 372(9648), 1463-1472 (2008). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 144.1 |
| 分子式 | C6H8O4 |
| CAS号 | 624-49-7 |
| 稳定性 | ≥ 2 years |
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