| 货号 | 13960-50mg |
| 描述 | Methotrexate (MTX) is an analog of folic acid and aminopterin that is used in the treatment of cancer, autoimmune diseases, ectopic pregnancy, and for the induction of medical abortions.1,2 It acts by inhibiting the metabolism of folic acid and blocking key enzymes in the synthesis of purines and pyrimidines required for cell proliferation.3,4 MTX is known to induce adenosine release, which mediates many of its anti-inflammatory effects including the reduction of proinflammatory cytokines.5,4,6 MTX is still considered the gold standard of DMARD (disease-modifying antirheumatic drug) therapy to treat both the immune-inflammatory and joint destructive processes of rheumatoid arthritis.7 |
| 别名 | Amethopterin;CL 14,377;EMT 25299;MTX;NSC 740;R 9985; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Cutolo, M.,Sulli, A.,Pizzorni, C., et al. Anti-inflammatory mechanisms of methotrexate in rheumatoid arthritis. Ann. Rheum. Dis. 60(8), 729-735 (2001). 2.Christin-Maitre, S.,Bouchard, P. and Spitz, I.M. Medical termination of pregnancy. N. Engl. J. Med. 342(13), 946-956 (2000). 3.Tian, H. and Cronstein, B.N. Understanding the mechanisms of action of methotrexate: Implications for the treatment of rheumatoid arthritis. Bull. NYU Hosp. Jt. Dis. 65(3), 168-173 (2007). 4.Swierkot, J. and Szechinski, J. Methotrexate in rheumatoid arthritis. Pharmacol. Rep. 58(4), 473-492 (2006). 5.Chan, E.S.L. and Cronstein, B.N. Molecular action of methotrexate in inflammatory diseases. Arthritis Res. 4(4), 266-273 (2002). 6.Wessels, J.A.M.,Huizinga, T.W.J. and Guchelaar, H.J. Recent insights in the pharmacological actions of methotrexate in the treatment of rheumatoid arthritis. Rheumatology 47, 249-255 (2008). 7.Smolen, J.S. and Steiner, G. Therapeutic strategies for rheumatoid arthritis. Nat. Rev. Drug Dis. 2(6), 473-488 (2003). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 454.4 |
| 分子式 | C20H22N8O5 |
| CAS号 | 59-05-2 |
| 稳定性 | ≥ 2 years |
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