OU749
货号：
13804-1mg 基本售价：
252.0 元 规格：
1 mg
产品信息
概述| 货号 | 13804-1mg |
| 描述 | γ-Glutamyl transferase (GGT) is involved in the transfer of amino acids across the plasma membrane as well as in glutathione metabolism.1 Serum GGT activity is commonly used as a marker of liver dysfunction and alcohol abuse. It is also useful as a biomarker of type 2 diabetes and cardiovascular disease.1 OU749 is a non-competitive inhibitor of GGT, exhibiting a Ki value of 17.6 μM.2 It is 150-fold less toxic than the GGT inhibitor acivicin toward dividing cells. OU749 inhibits human GGT 7- to 10-fold more potently than rat or murine GGT and does not inhibit porcine GGT.2 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Targher, G. Elevated serum γ-glutamyltransferase activity is associated with increased risk of mortality, incident type 2 diabetes, cardiovascular events, chronic kidney disease and cancer - a narrative review. Clinical Chemistry & Laboratory Medicine 48(2), 147-157 (2010).
2.King, J.B.,West, M.B.,Cook, P.F., et al. A novel, species-specific class of uncompetitive inhibitors of γ-glutamyl transpeptidase. The Journal of Biological Chemisty 284(14), 9059-9065 (2009).
|
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 361.4 |
| 分子式 | C16H15N3O3S2 |
| CAS号 | 519170-13-9 |
| 稳定性 | ≥ 2 years |
声明| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |
