(±)-Warfarin
货号：
13566-1g 基本售价：
252.0 元 规格：
1 g
产品信息
概述| 货号 | 13566-1g |
| 描述 | Warfarin is an anti-coagulant used to prevent heart attacks, strokes, and the formation of blood clots. It interferes with the use of vitamin K in the required carboxylation of several vitamin K-dependent proteins in the clotting cascade, preventing the initiating of clotting.1 (±)-Warfarin is a racemic mixture of 2 optically active isomers. (±)-Warfarin has a half-life of 36-42 hours in circulation,2 bound to plasma proteins, and accumulates in the liver, where the two isomers are metabolized by different pathways.3 Genetic differences in metabolic enzymes, drugs, diet, and disease state can affect the clearance, and thus the response, to warfarin. As a result, levels of the two enantiomers must be monitored carefully. (±)-Warfarin is also used as a rodenticide. |
| 别名 | Athrombine K;Coumadin;Coumafene;WARF 42;Zoocoumarin; |
| 是否危险品 | 是 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Hirsh, J.,Fuster, V.,Ansell, J., et al. American heart association/american college of cardiology foundation guide to warfarin therapy. J. Am. Coll. Cardiol. 41(9), 1633-1652 (2003).
2.Ufer, M. Comparative pharmacokinetics of vitamin K antagonists warfarin, phenprocoumon and acenocoumarol. Clinical Pharmacokinetics 44(12), 1227-1246 (2005).
3.Toon, S.,Low, L.K.,Gibaldi, M., et al. The warfarin-sulfinpyrazone interaction: Stereochemical considerations. Clinical Pharmacology and Therapeutics 39, 15-24 (1986).
|
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 308.3 |
| 分子式 | C19H16O4 |
| CAS号 | 81-81-2 |
| 稳定性 | ≥ 2 years |
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